CO-SAM Study: An adaptive multi-arm trial to reduce mortality and readmission among children with severe acute malnutrition in sub-Saharan Africa (CO-SAM)

We believe there is an urgent need to improve recovery in children with complicated severe acute malnutrition (SAM) after they leave hospital, by tackling underlying medical and social causes of ill-health. In this project, we bring together two networks of researchers from southern and east Africa with extensive experience in SAM.

This Phase III trial will start in 2023, enrolling 1000+ children with complicated SAM in Zambia, Zimbabwe and Kenya.

Five interventions:

  • Standard of care (double size)
  • Antimicrobial
  • Reformulated ready-to-use therapeutic food (RUTF)
  • Psychosocial
  • Combined