HIV-exposed uninfected (HEU) children are HIV-negative children born to HIV-positive mothers. Despite avoiding HIV infection, HEU children in sub-Saharan Africa have more infectious morbidity and mortality and poorer growth than HIV-unexposed children.
Our work at Zvitambo aims to describe the clinical outcomes of this group of children by comparing morbidity and growth between HEU and and HIV-unexposed children recruited to the SHINE trial. We will then undertake laboratory work to identify the drivers of poorer outcomes, focussing on immunological parameters.
Our previous work on HEU infants includes:
Prendergast AJ. Chasekwa B, Rukobo S, Govha M, Mutasa K, Ntozini R, Humphrey JH. Intestinal Damage and Inflammatory Biomarkers in Human Immunodeficiency Virus (HIV)–Exposed and HIV-Infected Zimbabwean Infants. Journal of Infectious Diseases 2017; 216 (6): 651-61.
Evans C, Chasekwa B, Rukobo S, Govha M, Mutasa K, Ntozini R, Humphrey JH, Prendergast AJ. CMV acquisition and inflammation in HIV-exposed uninfected Zimbabwean infants. Journal of Infectious Diseases 2017; 215 (5): 698-702.
Omoni AO, Ntozini R, Evans C, Prendergast AJ, Moulton LH, Christian PS, Humphrey JH. Child growth according to maternal and child HIV status in Zimbabwe. Pediatric Infectious Disease Journal (in press, 2017).
Evans C, Chasekwa B, Ntozini R, Humphrey JH, Prendergast AJ. Head circumferences of children born to HIV-infected and HIV-uninfected mothers in Zimbabwe during the pre-ART era. AIDS 2016; 30 (15): 2323-8.
Evans C, Humphrey JH, Ntozini R, Prendergast AJ. HIV-exposed uninfected infants in Zimbabwe: insights into health outcomes in the pre-antiretroviral therapy era. Frontiers in Immunology 2016; 7: 190.
Evans C, Jones CE, Prendergast AJ. HIV-exposed uninfected infants: new global challenges in the era of paediatric HIV elimination. Lancet Infectious Diseases 2016; 16 (6): e92-107.