Inflammation and epithelial repair predict mortality, hospital readmission, and growth recovery in complicated severe acute malnutrition

This paper examines the inflammatory changes in children following admission to hospital with severe acute malnutrition (SAM) 

• Inflammatory biomarkers remain abnormal for at least 48 weeks following discharge, compared with community controls
• This incudes inflammation across different body compartments, including acute inflammatory processes, and vascular inflammation.
• There is an interplay between this inflammation, and the levels of growth factors seen.
• The levels of the growth factors, in the face of this higher levels of inflammation, is correlated with better outcomes over that 48 weeks

Sturgeon JP, Tome J, Dumbura C, Majo FD, Ngosa D, Mutasa K, Zyambo K, Besa E, Chandwe K, Kapoma C, Mwapenya B, Nathoo KJ, Bourke CD, Ntozini R, Chasekwa B, Smuk M, Bwakura-Dangarembizi M, Amadi B, Kelly P, Prendergast AJ.